Item – Thèses Canada

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Numéro d'OCLC
897939298
Lien(s) vers le texte intégral
Exemplaire de BAC
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Auteur
De Koninck, Paul,
Titre
Factors that affect the extension of dendrites and the expression of nicotinic acetylcholine receptors by rat peripheral neurons
Diplôme
Ph. D. -- McGill University, 1995
Éditeur
[Montreal] : McGill University Libraries, [1995]
Description
1 online resource
Notes
Thesis supervisor: Cooper, Ellis (advisor).
Thesis supervisor: Carbonetto, Salvatore (advisor).
Includes bibliographical references.
Résumé
"The establishment of neuronal polarity constitutes a central phase in neuronal development and synaptogenesis. In my thesis, I study factors that regulate the development of neuronal polarity and its relationship with neurotransmitter receptor expression. For my experiments, I have investigated the development of sensory neurons from neonatal rat nodose ganglia in culture. Sensory neurons have a pseudo-unipolar morphology, do not extend dendrites, and are devoid of synaptic connections on their somata. However, nodose neurons form synapses de novo in cultures, and I show that the neurons have retained the ability to extend dendrites. Extrinsic factors control dendrite extension by these neurons: the ganglionic satellite cells inhibit the growth of dendrites and induce the neurons to develop a unipolar morphology. In the absence of satellite cells, nodose neurons establish a new multipolar morphology and, in response to nerve growth factor (NGF), extend several dendrites. However, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) do not induce the neurons to extend dendrites, but promote the expression of properties typical of nodose neurons in vivo."--
Autre lien(s)
digitool.Library.McGill.CA
digitool.library.mcgill.ca:8881
escholarship.mcgill.ca
escholarship.mcgill.ca
Sujet
Nicotinic receptors
Gene expression
Neurons Growth
Dendrites