Item – Thèses Canada

Numéro d'OCLC
728824512
Lien(s) vers le texte intégral
Exemplaire de BAC
Exemplaire de BAC
Auteur
Kamikovski, Ivan,1953-
Titre
Does the growth hormone-derived peptide AOD9604 have an anabolic effect on bone?.
Diplôme
M.A. Sc. -- University of Toronto, 2009
Éditeur
Ottawa :Library and Archives Canada = Bibliothèque et Archives Canada,[2010]
Description
2 microfiches
Notes
Includes bibliographical references.
Résumé
This study focused on the ability of AOD to rebuild the bone lost during ovariectomy (OVX) in a rat model of postmenopausal osteoporosis. Bone quality was evaluated through densitometry, mechanical testing, and techniques to assess remodeling, structural and material properties. We found that the anabolic effect of AOD was dose-dependent and site-specific. In cortical bone, AOD increased the cross-section of the femoral diaphysis via periosteal apposition without much effect on mechanical properties. In trabecular bone, AOD partially restored trabecular architecture, which resulted in an improvement in vertebral mechanical properties. In addition, AOD increased mineralization as well as stiffness and modulus of cortical and trabecular bone indicating that AOD may also have some anti-resorptive effect in addition to its anabolic effect.
ISBN
9780494526514
0494526513